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. Author manuscript; available in PMC: 2018 Jan 24.
Published in final edited form as: Nature. 2017 Jan 18;542(7639):60–65. doi: 10.1038/nature20819

Figure 2. An unusual voltage-sensor-like domain.

Figure 2

a, Amino acid sequence alignment of S4 and neighboring regions of the indicated channel subunits. Positions of positive charges in TAX-4 and Kv1.2–2.1 chimera are marked. b, c, Comparison of S4 of TAX-4 and the Kv1.2–2.1 chimera, viewed parallel to the membrane and after a 25-degree clockwise rotation from Fig. 1e. Positions R0-R6 in c correspond to R287, Q290, R293, R296, R299, K302 and R305, respectively. d, Ion-pair interactions involving the indicated TAX-4 S4 positive charges.