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. 2017 Nov 23;17(2):2113–2120. doi: 10.3892/mmr.2017.8145

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Therapeutic role of DNMT3b knockdown in vivo. (A) Cell viability was analyzed, and apoptosis was (B) quantified following (C) flow cytometry analysis in PANC-1 cells transfected with si-DNMT3b or NC. (D) Hoechst staining was performed to confirm the results of the viability and apoptosis assays. PANC-1 cells were used to establish a tumor model and the role of DNMT3b knockdown was determined in vivo through (E) observation and (F) measurement of tumor volume. *P<0.05, **P<0.01 vs. NC. Data are presented as the mean ± standard deviation. DNMT3b, DNA methyltransferase 3b; CCK-8, Cell Counting Kit-8; OD, optical density; siRNA, small interfering RNA; NC, negative control; FITC, fluorescein isothiocyanate; PI, propidium iodide.