Table II.
Association between levels of microRNA-223 and clinicopathological variables in patients with HCC from The Cancer Genome Atlas database.
| Parameter | n | Mean ± SD | T-value | P-value |
|---|---|---|---|---|
| Group | <0.001 | |||
| HCC | 371 | 9.112±1.436 | 8.659 | |
| Normal | 50 | 10.300±0.811 | ||
| Sex | 0.736 | |||
| Male | 252 | 9.095±1.426 | 0.337 | |
| Female | 119 | 9.149±1.462 | ||
| Tumor status | 0.625 | |||
| Tumor present | 111 | 9.116±1.531 | 0.489 | |
| Tumor-free | 233 | 9.037±1.327 | ||
| Family history | 0.174 | |||
| + | 110 | 9.284±1.479 | 1.361 | |
| − | 210 | 9.053±1.427 | ||
| Risk factors | 0.734 | |||
| + | 251 | 9.092±1.435 | 0.339 | |
| − | 101 | 9.149±1.435 | ||
| Other malignancy | 0.485 | |||
| + | 36 | 9.271±1.446 | 0.700 | |
| − | 335 | 9.095±1.436 | ||
| Inflammation | 0.749 | |||
| + | 117 | 9.060±1.418 | 0.321 | |
| − | 118 | 9.000±1.483 | ||
| Ethnicity | 0.650 | |||
| Hispanic or Latino | 18 | 9.297±1.844 | 0.461 | |
| Non-Hispanic or Latino | 334 | 9.094±1.418 | ||
| T stage | 0.981 | |||
| G I–II | 275 | 9.105±1.295 | 0.024 | |
| G III–IV | 93 | 9.109±1.812 | ||
| N stage | 0.894 | |||
| N1 | 4 | 9.190±1.300 | 0.133 | |
| NX-N0 | 254 | 9.093±1.446 | ||
| M stage | 0.286 | |||
| M1 | 4 | 8.324±0.844 | 1.069 | |
| MX-M0 | 269 | 9.087±1.423 | ||
| Pathologic stage | 0.913 | |||
| Stage I–II | 260 | 9.084±1.296 | 0.110 | |
| Stage III–IV | 87 | 9.108±1.875 | ||
| Vascular invasion | 0.214 | |||
| + | 110 | 9.227±1.635 | 1.247 | |
| − | 206 | 9.002±1.298 |
HCC, hepatocellular carcinoma; T stage, size or direct extent of the primary tumor; N stage, degree of spread to regional lymph nodes; M stage, presence of distant metastasis; SD, standard deviation.