Table V.

Diagnostic value of mcroiRNA-223 in 19 individual studies.

ID	Author/source, year	HCC (n)	Controls (n)	AUC	Sensitivity	Specificity	TP (n)	FP (n)	FN (n)	TN (n)	(Refs.)
1	Khairy et al, 2016	23	55	0.680	0.960	0.509	22	27	1	28	(53)
2	Bhattacharya et al, 2016	39	17	0.997	0.972	0.941	39	0	0	17	(37)
3	Bhattacharya et al, 2016	39	14	1.000	1.000	1.000	38	1	1	13	(37)
4	Duo et al, 2015	90	30	NA	0.800	0.900	72	3	18	27	(54)
5	Duo et al, 2015	90	30	NA	0.730	0.833	66	5	24	25	(54)
6	Duo et al, 2015	90	60	NA	0.719	0.833	65	10	25	50	(54)
7	GSE12717, 2008	10	6	0.883	0.800	1.000	8	0	2	6	–
8	GSE20971, 2011	49	9	0.673	0.531	0.778	26	2	23	7	–
9	GSE21279, 2010	4	11	0.568	1.000	0.364	4	7	0	4	–
10	GSE21362, 2011	73	73	0.824	0.726	0.904	53	7	20	66	–
11	GSE39678, 2012	16	8	0.875	0.750	1.000	12	0	4	8	–
12	GSE41874, 2013	6	4	0.625	0.667	0.750	4	1	2	3	–
13	GSE54751, 2014	10	10	0.890	0.700	1.000	7	0	3	10	–
14	GSE57555, 2015	5	16	0.825	1.000	0.562	5	7	0	9	–
15	GSE65708, 2016	6	8	0.813	0.833	0.750	5	2	1	6	–
16	GSE6857, 2008	241	241	0.597	0.340	0.855	82	35	159	206	–
17	GSE69580, 2015	5	5	0.560	0.600	0.800	3	1	2	4	–
18	GSE74618, 2016	218	20	0.731	0.729	0.750	159	5	59	15	–
19	TCGA, 2016	375	50	0.782	0.667	0.860	250	7	125	43	–

HCC, hepatocellular carcinoma; AUC, area under the curve; TP, true positive; FP, false positive; TN, true negative; FN, false negative; NA, not applicable.