Table VIII.

Ten prominent protein-protein interaction nodes according to the Search Tool for the Retrieval of Interacting Genes.

Node 1	Node 2	Co-expression	Experimentally determined interaction	Database annotated	Automated textmining	Combined score
DNMT1	DNMT3A	0	0.798	0.9	0.987	0.999
RACGAP1	ECT2	0.288	0.914	0.9	0.907	0.999
RACGAP1	KIF23	0.578	0.996	0.9	0.979	0.999
KIF23	ECT2	0.245	0.564	0.9	0.966	0.998
E2F1	CCNE2	0	0.363	0.9	0.735	0.981
BIRC5	KIF23	0.161	0	0.9	0.738	0.976
AXIN2	LEF1	0	0.110	0.9	0.751	0.976
RACGAP1	BIRC5	0.173	0	0.9	0.714	0.974
CHEK1	MCM6	0.093	0.207	0.9	0.562	0.964
DNMT1	E2F1	0.070	0.564	0.9	0.116	0.959

DNMT, DNA methyltransferase; RACGAP1, Rac GTPase-activating protein 1; KIF23, kinesin family member 23; BIRC5, baculoviral IAP repeat containing 5; CHEK1, checkpoint kinase 1; CCNE2, cyclin E2; LEF1, lymphoid enhancer-binding factor 1; MCM6, minichromosome maintenance complex component 6.