Table II.
GO functional annotation of the target genes of miR-338-5p from Cytoskape.
| ID | Category | GO term | P-value | Count |
|---|---|---|---|---|
| GO:0006082 | GO_Biological process | Organic acid metabolic process | 3.87×10−9 | 37 |
| GO:0016054 | GO_Biological process | Organic acid catabolic process | 6.26×10−9 | 16 |
| GO:0008152 | GO_Biological process | Metabolic process | 1.29×10−3 | 159 |
| GO:0009056 | GO_Biological process | Catabolic process | 1.15×10−1 | 28 |
| GO:0007275 | GO_Biological process | Multicellular organismal development | 1.11×10−6 | 102 |
| GO:0048731 | GO_Biological process | System development | 9.71×10−8 | 91 |
| GO:0048519 | GO_Biological process | Negative regulation of biological process | 1.82×10−5 | 72 |
| GO:0048523 | GO_Biological process | Negative regulation of cellular process | 3.81×10−5 | 66 |
| GO:0050789 | GO_Biological process | Regulation of biological process | 3.62×10−4 | 176 |
| GO:0065007 | GO_Biological process | Biological regulation | 6.72×10−5 | 189 |
| GO:0008150 | GO_Biological process | Biological_process | 1.15×10−3 | 336 |
| GO:0032501 | GO_Biological process | Multicellular organismal process | 1.15×10−5 | 133 |
| GO:0044237 | GO_Biological process | Cellular metabolic process | 6.22×10−3 | 132 |
| GO:0034641 | GO_Biological process | Cellular nitrogen compound metabolic process | 2.19×10−2 | 59 |
| GO:0044238 | GO_Biological process | Primary metabolic process | 4.35×10−3 | 140 |
| GO:0050896 | GO_Biological process | Response to stimulus | 4.59×10−5 | 112 |
| GO:0009719 | GO_Biological process | Response to endogenous stimulus | 3.77×10−9 | 34 |
| GO:0050794 | GO_Biological process | Regulation of cellular process | 9.14×10−4 | 166 |
| GO:0023052 | GO_Biological process | Signaling | 5.63×10−5 | 99 |
| GO:0044281 | GO_Biological process | Small molecule metabolic process | 3.29×10−8 | 62 |
| GO:0006519 | GO_Biological process | Cellular amino acid and derivative metabolic process | 5.92×10−5 | 21 |
| GO:0043436 | GO_Biological process | Oxoacid metabolic process | 2.77×10−9 | 37 |
| GO:0019752 | GO_Biological process | Carboxylic acid metabolic process | 2.77×10−9 | 37 |
| GO:0009987 | GO_Biological process | Cellular process | 2.40×10−8 | 258 |
| GO:0046395 | GO_Biological process | Carboxylic acid catabolic process | 6.26×10−9 | 16 |
| GO:0009063 | GO_Biological process | Cellular amino acid catabolic process | 2.78×10−6 | 10 |
| GO:0044248 | GO_Biological process | Cellular catabolic process | 3.54×10−2 | 25 |
| GO:0009725 | GO_Biological process | Response to hormone stimulus | 4.39×10−8 | 30 |
| GO:0048545 | GO_Biological process | Response to steroid hormone stimulus | 2.46×10−6 | 18 |
| GO:0006807 | GO_Biological process | Nitrogen compound metabolic process | 2.95×10−3 | 67 |
| GO:0006520 | GO_Biological process | Cellular amino acid metabolic process | 4.99×10−5 | 16 |
| GO:0009605 | GO_Biological process | Response to external stimulus | 1.81×10−8 | 35 |
| GO:0009308 | GO_Biological process | Amine metabolic process | 4.15×10−6 | 25 |
| GO:0009310 | GO_Biological process | Amine catabolic process | 9.50×10−6 | 10 |
| GO:0032502 | GO_Biological process | Developmental process | 5.43×10−7 | 110 |
| GO:0048856 | GO_Biological process | Anatomical structure development | 8.77×10−7 | 94 |
| GO:0009653 | GO_Biological process | Anatomical structure morphogenesis | 1.19×10−6 | 53 |
| GO:0042221 | GO_Biological process | Response to chemical stimulus | 3.51×10−10 | 70 |
| GO:0010033 | GO_Biological process | Response to organic substance | 4.09×10−11 | 52 |
| GO:0010646 | GO_Biological process | Regulation of cell communication | 1.30×10−5 | 48 |
| GO:0008283 | GO_Biological process | Cell proliferation | 3.68×10−6 | 26 |
| GO:0044282 | GO_Biological process | Small molecule catabolic process | 2.35×10−5 | 18 |
| GO:0023046 | GO_Biological process | Signaling process | 8.53×10−6 | 77 |
| GO:0023060 | GO_Biological process | Signal transmission | 8.53×10−6 | 77 |
| GO:0042127 | GO_Biological process | Regulation of cell proliferation | 1.66×10−6 | 41 |
| GO:0048513 | GO_Biological process | Organ development | 5.37×10−8 | 74 |
| GO:0009888 | GO_Biological process | Tissue development | 2.37×10−8 | 42 |
| GO:0044106 | GO_Biological process | Cellular amine metabolic process | 1.70×10−4 | 18 |
| GO:0032787 | GO_Biological process | Monocarboxylic acid metabolic process | 3.81×10−6 | 21 |
| GO:0007165 | GO_Biological process | Signal transduction | 2.88×10−6 | 71 |
| GO:0010648 | GO_Biological process | Negative regulation of cell communication | 3.44×10−6 | 22 |
| GO:0051239 | GO_Biological process | Regulation of multicellular organismal process | 1.60×10−6 | 48 |
| GO:0042180 | GO_Biological process | Cellular ketone metabolic process | 5.36×10−9 | 37 |
| GO:0050793 | GO_Biological process | Regulation of developmental process | 1.88×10−6 | 39 |
| GO:0005515 | GO_Molecular function | Protein binding | 2.06×10−6 | 223 |
| GO:0003674 | GO_Molecular function | Molecular_function | 4.03×10−4 | 359 |
| GO:0005488 | GO_Molecular function | Binding | 8.63×10−8 | 316 |
| GO:0048037 | GO_Molecular function | Cofactor binding | 3.31×10−6 | 19 |
| GO:0005102 | GO_Molecular function | Receptor binding | 1.45×10−7 | 46 |
| GO:0005575 | GO_Cellular component | Cellular_component | 1.14×10−2 | 370 |
| GO:0005615 | GO_Cellular component | Extracellular space | 1.96×10−8 | 42 |
| GO:0005576 | GO_Cellular component | Extracellular region | 1.10×10−5 | 73 |
| GO:0044421 | GO_Cellular component | Extracellular region part | 3.08×10−9 | 52 |
GO, Gene Ontology.