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. 2017 Dec 12;17(2):2937–2944. doi: 10.3892/mmr.2017.8270

Figure 4.

Figure 4.

Effect of COX-2 inhibition on TECS Compared to NECs and TECs. (A) qRT-PCR analysis of mRNA expression levels of VEGF in NECs, TECs and TECs + inhibitor. The values are expressed relative to those of NECs (n=3). (B) qRT-PCR analysis of mRNA expression and WB of protein expression levels of PFKFB3 in NECs, TECs and TECs + inhibitor. The values are expressed relative to those of NECs (n=3). (C) Glucose levels in the medium of TECs and TECs + inhibitor, relative to those of NECs (n=3). (D) Lactate levels in the medium of TECs and TECs + inhibitor, relative to those of NECs (n=3). All data are shown as the means ± SEM. *P<0.05. ECs, endothelial cells; TECs, tumor endothelial cells; VEGF, vascular endothelial growth factor; PFKFB3, fructose-2,6-bisphosphatase; NECs, normal endothelial cells.