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Knockdown of EPS8 attenuated the proliferation of K562 cells in vivo. BALB/c nude mice (n=8 for each group) were implanted subcutaneously with 1×107 K562-scramble or K562-shRNA-EPS8 cells. (A) The tumor volume was assessed every 3 days. (B) Mice were sacrificed on day 24 after inoculation and the subcutaneous tumors were weighed. Plots are representative of 2 independent experiments. *P<0.05 vs. the scramble control, **P<0.01, ***P<0.001; ****P<0.0001.
