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. 2017 Dec 11;39(2):491–500. doi: 10.3892/or.2017.6142

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Overexpression of HMGB1 partly abrogates miR-505-induced inhibitory effects on MG63 cells. (A) The expression of HMGB1 in different groups was detected by western blotting analyses. (B) Cell migration ability was detected by wound-healing assay in MG63 cells transfected with miR-505 mimics or miR-505 mimics/empty vector or miR-505 mimics/HMGB1. (C) MTT assay was performed in MG63 cells. (D) Transwell chamber was used for cell invasive ability detection. (E) Western blotting analyses were used to detect the expression of MMP-2/9 and cyclin D1 in MG63 cells. *P<0.01 compared with mimics/empty vector.