Table 7.

Odds ratios and 95% confidence intervals for quartiles of prenatal brominated flame retardant congener serum concentrations in association with ASD (relative to GP controls), stratified by child sex.

BFR/quartile	Males			Females			p-Interactiona
	Case/control ($n$/$n$)	Model 1b	Model 2c	Case/control ($n$/$n$)	Model 1	Model 2
BB153							0.83
Q1	93/76	1.0	1.0	21/17	1.0	1.0
Q2	95/74	1.05 (0.68, 1.61)	1.12 (0.72, 1. 75)	29/18	1.32 (0.55, 3.18)	1.27 (0.48, 3.37)
Q3	100/85	0.96 (0.63, 1.46)	0.85 (0.53, 1.36)	17/15	0.93 (0.36, 2.40)	0.99 (0.31, 3.20)
Q4	130/81	1.31 (0.87, 1.99)	1.10 (0.72, 1. 69)	24/17	1.17 (0.47, 2.89)	1.19 (0.37, 3.78)
BDE-28							0.02
Q1	122/76	1.0	1.0	20/18	1.0	1.0
Q2	104/74	0.87 (0.58, 1.32)	0.94 (0.61, 1.44)	26/19	1.23 (0.52, 2.96)	0.92 (0.34, 2.46)
Q3	95/72	0.82 (0.54, 1.25)	0.91 (0.59, 1.40)	19/18	0.96 (0.39, 2.41)	0.70 (0.25, 2.00)
Q4	92/89	0.64 (0.42, 0.97)	0.70 (0.45, 1.07)	24/10	2.20 (0.82, 5.92)	2.58 (0.86, 7.79)
BDE-47							0.02
Q1	152/81	1.0	1.0*	26/22	1.0	1.0+
Q2	108/89	0.64 (0.44, 0.95)	0.70 (0.47, 1.04)	26/16	1.37 (0.59, 3.19)	1.31 (0.50, 3.43)
Q3	95/82	0.61 (0.41, 0.92)	0.69 (0.47, 1.00)	21/22	0.78 (0.34, 1.81)	0.89 (0.34, 2.31)
Q4	91/91	0.53 (0.36, 0.79)	0.72 (0.50, 1.05)	26/13	1.66 (0.69, 4.00)	2.64 (0.97, 7.19)
BDE-99							0.04
Q1	150/80	1.0	1.0*	27/20	1.0	1.0
Q2	111/85	0.69 (0.47, 1.03)	0.74 (0.50, 1.11)	19/18	0.77 (0.32, 1.85)	0.86 (0.32, 2.30)
Q3	87/83	0.55 (0.37, 0.83)	0.61 (0.40, 0.93)	29/19	1.13 (0.50, 2.58)	1.81 (0.70, 4.69)
Q4	88/88	0.53 (0.36, 0.79)	0.60 (0.39, 0.90)	22/14	1.16 (0.48, 2.82)	1.98 (0.71, 5.56)
BDE-100							0.03
Q1	151/80	1.0	1.0*	30/19	1.0	1.0
Q2	101/81	0.66 (0.44, 0.98)	0.72 (0.48, 1.08)	15/21	0.45 (0.19, 1.08)	0.51 (0.19, 1.38)
Q3	92/86	0.57 (0.38, 0.84)	0.61 (0.40, 0.91)	28/17	1.05 (0.45, 2.44)	1.56 (0.59, 4.17)
Q4	92/89	0.55 (0.37, 0.81)	0.61 (0.40, 0.92)	24/14	1.09 (0.45, 2.62)	1.62 (0.59, 4.42)
BDE-153							0.02
Q1	152/72	1.0	1.0*	27/23	1.0	1.0
Q2	90/88	0.48 (0.32, 0.73)	0.48 (0.32, 0.73)	26/15	1.48 (0.64, 3.44)	2.12 (0.82, 5.52)
Q3	111/87	0.61 (0.41, 0.90)	0.64 (0.43, 0.97)	23/20	0.96 (0.42, 2.20)	1.20 (0.45, 3.23)
Q4	83/89	0.44 (0.29, 0.67)	0.45 (0.29, 0.70)	21/13	1.35 (0.55, 3.31)	2.04 (0.71, 5.84)
Sumd							0.03
Q1	143/75	1.0	1.0*	29/20	1.0	1.0
Q2	90/78	0.79 (0.54, 1.16)	0.82 (0.55, 1.22)	22/17	0.94 (0.42, 2.09)	1.03 (0.41, 2.59)
Q3	117/78	0.92 (0.63, 1.35)	1.02 (0.69, 1.50)	22/17	0.91 (0.41, 2.05)	1.28 (0.51, 3.20)
Q4	68/85	0.52 (0.35, 0.78)	0.57 (0.37, 0.86)	16/11	1.04 (0.42, 2.57)	1.42 (0.51, 3.98)

Note: GP, general population.

^ap-Interaction term for BFR concentration (ordinal median value variable) by sex, adjusted as in Model 2, including males and females.

^bModel 1: logistic regression adjusted for child month and year of birth.

^cModel 2 (estimates as shown in Figure 1): $\text{Model}1+\text{maternal}\text{age}$, maternal race/ethnicity, maternal weight at time of sample collection, parity, and maternal education.

^dSum of congeners listed in table (detected in $>55\%$ of the study population).

^*$p<0.05$ in test for trend across quartiles.