Table 2.
BP-Associated SNPs Associated With Expression of the Same Gene Across 4 or 3 Independent Whole-Blood eQTL Resources and the Kidney Resource
| Sentinel SNP | Chr | Position | Gene | Blood Data Sets | Top eQTL | Signal in Other Tissue(s) in GTEx |
Signal in Kidney |
eQTL Signal Previously Reported |
|---|---|---|---|---|---|---|---|---|
| Signal in 4 whole-blood eQTL resources | ||||||||
| rs17367504 | 1 | 11862778 | CLCN6 | YYYY | Y | Y | ||
| rs2169137 | 1 | 204497913 | MDM4 | YYYY | Y | Y | Y | |
| rs10926988 | 1 | 243483279 | SDCCAG8 | YYYY | Y | |||
| rs319690 | 3 | 47927484 | MAP4 | YYYY | Y | Y | Y | |
| rs12521868 | 5 | 131784393 | SLC22A5 | YYYY | Y | |||
| rs900145 | 11 | 13293905 | ARNTL | YYYY | Y | Y | ||
| rs1060105 | 12 | 123806219 | CDK2AP1 | YYYY | Y | Y | Y | |
| rs1378942 | 15 | 75077367 | SCAMP2 | YYYY | ||||
| rs1126464 | 16 | 89704365 | CHMP1A | YYYY | Y | Y | ||
| rs1126464 | 16 | 89704365 | FANCA | YYYY | Y | |||
| rs12946454 | 17 | 43208121 | DCAKD | YYYY | Y | Y | Y | |
| Signal in 3 (out of 4) whole-blood eQTL resources | ||||||||
| rs17367504 | 1 | 11862778 | MTHFR | YYYN | Y | Y | ||
| rs871524 | 1 | 38411445 | FHL3 | NYYY | Y | |||
| rs871524 | 1 | 38411445 | SF3A3 | NYYY | Y | |||
| rs4660293 | 1 | 40028180 | PABPC4 | YYYN | Y | Y | Y | |
| rs6749447 | 2 | 169041386 | STK39 | YYYN | Y | |||
| rs347591 | 3 | 11290122 | ATG7 | YYYN | Y | |||
| rs319690 | 3 | 47927484 | ZNF589 | YYNY | Y | |||
| rs12521868 | 5 | 131784393 | SLC22A4 | YYYN | Y | |||
| rs1563788 | 6 | 43308363 | CRIP3 | YYYN | Y | Y | ||
| rs10943605 | 6 | 79655477 | PHIP | YYYN | Y | Y | Y | |
| rs4728142 | 7 | 128573967 | IRF5 | NYYY | Y | Y | Y | |
| rs4728142 | 7 | 128573967 | TNPO3 | YYYN | Y | |||
| rs2898290 | 8 | 11433909 | BLK | YYYN | Y | |||
| rs2898290 | 8 | 11433909 | FAM167A | NYYY | Y | |||
| rs2898290 | 8 | 11433909 | FDFT1 | YYYN | Y | |||
| rs2071518 | 8 | 120435812 | NOV | YYYN | Y | |||
| rs76452347 | 9 | 35906471 | TPM2 | YYYN | ||||
| rs10760117 | 9 | 123586737 | MEGF9 | YYYN | Y | Y | ||
| rs4494250 | 10 | 96563757 | HELLS | YYYN | Y | |||
| rs11191548 | 10 | 104846178 | NT5C2 | YYYN | Y | |||
| rs661348 | 11 | 1905292 | TNNT3 | NYYY | Y | |||
| rs2649044 | 11 | 9763969 | SBF2 | YYYN | ||||
| rs2649044 | 11 | 9763969 | SWAP70 | YYYN | Y | Y | ? | |
| rs7129220 | 11 | 10350538 | ADM | YYYN | Y | |||
| rs7103648 | 11 | 47461783 | MYBPC3 | YYYN | ||||
| rs3741378 | 11 | 65408937 | CTSW | YYYN | ||||
| rs7302981 | 12 | 50537815 | LIMA1 | YYYN | Y | |||
| rs7302981 | 12 | 50537815 | ATF1 | YYNY | Y | |||
| rs1036477 | 15 | 48914926 | FBN1 | YNYY | ||||
| rs1378942 | 15 | 75077367 | CSK | YYYN | Y | Y | Y | |
| rs1378942 | 15 | 75077367 | MPI | NYYY | Y | |||
| rs1378942 | 15 | 75077367 | ULK3 | YNYY | Y | Y | ||
| rs12946454 | 17 | 43208121 | NMT1 | YYYN | Y | |||
| rs2304130 | 19 | 19789528 | GATAD2A | YYYN | ||||
| rs867186 | 20 | 33764554 | EIF6 | NYYY | Y | |||
| rs6095241 | 20 | 47308798 | PREX1 | YYYN | ||||
| rs9306160 | 21 | 45107562 | RRP1B | YNYY | Y | Y | ||
Signals of association of SNP genotype and gene expression in other nonblood tissues in GTEx and in kidney are also indicated. Blood data set order: (1) SABRe, (2) NESDA-NTR, (3) BIOS, and (4) GTEx (whole-blood). Top eQTL: top GWAS SNP is top eQTL SNP (or in high LD, r2>0.9, with top eQTL SNP) in at least 1 data set. eQTL signal previously reported: Genes for which eQTL signals have been previously reported for that sentinel SNP.15,16,18 For full list, see Table S12 in the online-only Data Supplement. eQTL indicates expression quantitative trait loci; GWAS, genome-wide association studies; GTEx, genotype-tissue expression; and LD, linkage disequilibrium; and SABRe, Systems Approach to Biomarker Research in Cardiovascular Disease.