Table 2.
Experimental design with response values for buccal tablet formulations.
| Code | Independent variables |
Responses |
||||||
|---|---|---|---|---|---|---|---|---|
| Carbopol (X1) | Chitosan (X2) | Dis.*** (water) (min) | Dis.* (Ar. Sal.) (min) | Swelling | t85%** (min) | Peak Det. For.* (N) | Permeation (%) | |
| F1 | 5 (0) | 15 (+1) | 210 ± 8 | 226 ± 6 | 4.59 ± 0.442 | 1206 ± 25 | 2.79 ± 0.05 | 7.29 ± 0.34 |
| F2 | 5 (0) | 7.5 (0) | 201 ± 4 | 212 ± 7 | 4.97 ± 0.223 | 2260 ± 126 | 1.21 ± 0.17 | 4.91 ± 0.03 |
| F3 | 10 (+1) | 0 (−1) | 203 ± 11 | 226 ± 3 | 7.11 ± 0.274 | 2191 ± 61 | 4.80 ± 0.56 | 1.82 ± 0.40 |
| F4 | 0 (−1) | 15 (+1) | 190 ± 2 | 186 ± 5 | 1.60 ± 0.12 | 14 ± 2 | 0.79 ± 0.15 | 12.77 ± 0.99 |
| F5 | 0 (−1) | 0 (−1) | 8 ± 1 | 4 ± 2 | 0.73 ± 0.114 | 9 ± 1 | 0.37 ± 0.08 | 9.26 ± 0.39 |
| F6 | 5 (0) | 0 (−1) | 170 ± 4 | 174 ± 5 | 5.69 ± 0.345 | 1462 ± 48 | 1.76 ± 0.14 | 3.82 ± 0.23 |
| F7 | 0 (−1) | 7.5 (0) | 92 ± 6 | 87 ± 6 | 1.81 ± 0.105 | 14 ± 1 | 0.47 ± 0.05 | 13.01 ± 0.20 |
| F8 | 10 (+1) | 15 (+1) | 204 ± 6 | 211 ± 4 | 7.91 ± 0.305 | 1328 ± 23 | 4.24 ± 0.16 | 1.69 ± 0.12 |
| F9 | 10 (+1) | 7.5 (0) | 178 ± 8 | 199 ± 5 | 7.85 ± 0.294 | 2245 ± 46 | 4.63 ± 0.13 | 1.73 ± 0.11 |
(+1) high values, (0) medium values and (−1) low values
Peak Det. For.* = Peak Detachment Force.
Dissolution** = USP Paddle Method Results.
Dis*** = Disintegration.
Mean ± SD.