Table 3.

Summary of the response parameters.

Source	Sum of squares	df	Mean square	F	Prob > F	r2
(a) Disintegration time in water (Model: 2FI)
Model	30982.58	3	10327.53	8.60	0.0204*	0.8376
X1	14504.17	1	14504.17	12.07	0.0178*
X2	8288.17	1	8288.17	6.90	0.4670
X1X2	8190.25	1	8190.25	6.82	0.4760
(b) Disintegration time in artificial saliva (Model: Quadratic)
Model	44602.69	5	8920.54	39.97	0.0060*	0.9852
X1	21480.17	1	21480.17	96.25	0.0023*
X2	7993.50	1	7993.50	35.82	0.0093*
X1X2	9702.25	1	9702.25	43.47	0.0071*
X12	5373.39	1	5373.39	24.08	0.0162*
X22	53.39	1	53.39	0.24	0.6583
(c) Swelling capacity (Model: Linear)
Model	58.54	2	29.27	76.76	<0.0001*	0.9624
X1	58.48	1	58.48	153.38	<0.0001*
X2	0.05	1	0.05	0.14	0.7197
(c) 85% Dissolution time (min) (Model: Linear)
Model	5673254	2	2836627	9.246711	0.0147*	0.7550
X1	5466422	1	5466422	17.8192	0.0056*
X2	206832.7	1	206832.7	0.674224	0.4430
(d) Peak detachment force (Model: Linear)
Model	24.29	2	2.12	32.98	0.0006*	0.9166
X1	24.16	1	24.16	65.61	0.0002*
X2	0.13	1	0.13	0.36	0.5712
(e) Permeation% at 360 min (Model: Linear)
Model	155.92	2	77.96	42.18	0.0003*	0.9336
X1	148.14	1	148.14	80.14	0.0001*
X2	7.78	1	7.78	4.21	0.0861

X1 and X2 represent amount of Carbopol (mg) and Chitosan (mg) and X1X2 is the interaction effect.

df indicates degree of freedom.

^*Significant factors.