Table 6.
Cell line | Concentration (µg/ml) | Cell viability (%) |
||||||
---|---|---|---|---|---|---|---|---|
Total (Ethanol) | Lipoidal matters | Chloro-form | n-butanol | Aqueous | Powder | Vinblastine sulfate | ||
A-549 Lung carcinoma |
000.00 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
001.00 | 100 | 98.1 | 100 | 100 | 100 | 100 | 98.2 | |
002.00 | 98.1 | 92.3 | 100 | 100 | 100 | 100 | 94.7 | |
003.90 | 94.0 | 84.9 | 98.6 | 100 | 100 | 98.4 | 81.4 | |
007.80 | 87.3 | 67.2 | 93.7 | 100 | 98.1 | 91.7 | 73.8 | |
015.60 | 76.9 | 48.6 | 85.1 | 99.2 | 92.8 | 85.0 | 62.5 | |
031.25 | 63.1 | 40.9 | 70.4 | 95.0 | 84.0 | 72.3 | 40.7 | |
062.50 | 41.9 | 32.8 | 54.8 | 89.4 | 69.5 | 59.1 | 32.9 | |
125.00 | 30.6 | 21.9 | 38.7 | 68.1 | 42.7 | 38.6 | 25.2 | |
250.00 | 22.8 | 12.8 | 23.8 | 40.7 | 29.4 | 23.1 | 15.3 | |
500.00 | 10.7 | 06.3 | 12.9 | 27.8 | 14.5 | 10.9 | 06.8 | |
CACO-2 Intestinal carcinoma |
IC50 (µg/ml) | 50.7 ± 3.5 | 15 ± 1.7 | 81.4 ± 4.5 | 208 ± 17.2 | 108 ± 9.2 | 90.4 ± 7.8 | 24.6 ± 0.7 |
000.00 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |
001.00 | 100 | 100 | 100 | 100 | 100 | 100 | 99.2 | |
002.00 | 100 | 98.7 | 100 | 100 | 100 | 100 | 93.8 | |
003.90 | 100 | 95.4 | 100 | 100 | 97.8 | 100 | 86.2 | |
007.80 | 99.4 | 89.2 | 99.4 | 97.4 | 92.4 | 99.4 | 79.4 | |
015.60 | 96.1 | 72.3 | 95.2 | 90.6 | 85.2 | 96.2 | 67.5 | |
031.25 | 89.2 | 49.2 | 84.1 | 81.4 | 78.1 | 89.7 | 48.9 | |
062.50 | 72.5 | 38.4 | 70.6 | 68.0 | 65.7 | 70.8 | 31.4 | |
125.00 | 43.8 | 27.1 | 53.4 | 47.1 | 42.9 | 42.9 | 20.3 | |
250.00 | 31.7 | 14.2 | 34.9 | 36.2 | 28.7 | 28.8 | 08.9 | |
500.00 | 16.4 | 06.4 | 23.6 | 21.4 | 12.5 | 15.2 | 04.0 | |
IC50 (µg/ml) | 112 ± 10.4 | 30.7 ± 4.1 | 149 ± 12.2 | 117 ± 9.1 | 106 ± 8.4 | 109 ± 11.4 | 30.3 ± 1.4 | |
HCT-116 Colon carcinoma |
000.00 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
001.00 | 100 | 79.4 | 100 | 100 | 100 | 100 | 66.4 | |
002.00 | 100 | 72.9 | 100 | 100 | 100 | 100 | 58.1 | |
003.90 | 98.7 | 60.7 | 100 | 100 | 100 | 98.7 | 47.3 | |
007.80 | 93.2 | 45.9 | 99.1 | 98.1 | 100 | 95.1 | 39.8 | |
015.60 | 86.9 | 38.2 | 93.7 | 91.8 | 99.7 | 89.5 | 28.7 | |
031.25 | 69.1 | 30.6 | 86.0 | 85.2 | 92.4 | 73.1 | 18.9 | |
062.50 | 43.5 | 22.8 | 68.1 | 68.0 | 69.5 | 49.5 | 15.5 | |
125.00 | 30.7 | 16.4 | 45.2 | 49.8 | 42.8 | 36.9 | 12.1 | |
250.00 | 18.6 | 08.7 | 31.7 | 35.4 | 24.9 | 23.8 | 06.7 | |
500.00 | 06. | 03.9 | 18.6 | 23.8 | 08.7 | 09.2 | 04.0 | |
IC50 (µg/ml) | 54.7 ± 1.2 | 6.7 ± 0.2 | 112 ± 7.2 | 125 ± 5.3 | 108 ± 3.9 | 61.9 ± 3.1 | 3.5 ± 0.2 | |
HeLa Cervical carcinoma |
000.00 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
001.00 | 100 | 92.5 | 100 | 100 | 100 | 100 | 100 | |
002.00 | 99.5 | 81.4 | 100 | 100 | 100 | 100 | 98.1 | |
003.90 | 94.6 | 69.0 | 99.4 | 100 | 100 | 98.4 | 95.4 | |
007.80 | 89.7 | 52.7 | 96.0 | 100 | 97.8 | 92.3 | 90.6 | |
015.60 | 80.9 | 43.9 | 88.9 | 100 | 91.3 | 81.4 | 82.7 | |
031.25 | 65.2 | 35.1 | 80.7 | 100 | 80.6 | 69.8 | 71.9 | |
062.50 | 48.1 | 26.7 | 68.9 | 100 | 62.9 | 45.1 | 47.8 | |
125.00 | 31.4 | 18.4 | 47.5 | 100 | 43.0 | 30.6 | 34.5 | |
250.00 | 14.7 | 09.6 | 31.7 | 97.1 | 29.4 | 21.8 | 22.8 | |
500.00 | 08.9 | 05.7 | 17.2 | 89.2 | 15.8 | 09.2 | 09.1 | |
IC50 (µg/ml) | 59.1 ± 3.2 | 10.2 ± 0.6 | 118 ± 5.1 | > 500 | 103 ± 4.8 | 56.3 ± 3.4 | 59.7 ± 2.1 | |
HepG-2 Hepatocellular carcinoma |
000.00 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
001.00 | 100 | 90.6 | 100 | 100 | 100 | 100 | 60.9 | |
002.00 | 98.2 | 83.1 | 100 | 100 | 100 | 98.7 | 54.2 | |
003.90 | 91.7 | 70.4 | 99.3 | 100 | 98.6 | 94.0 | 45.0 | |
007.80 | 80.1 | 49.2 | 94.1 | 100 | 91.7 | 88.7 | 34.1 | |
015.60 | 69.4 | 37.0 | 86.2 | 100 | 82.0 | 72.1 | 26.8 | |
031.25 | 48.1 | 28.5 | 72.6 | 100 | 67.4 | 48.5 | 19.2 | |
062.50 | 34.5 | 20.6 | 51.3 | 100 | 53.9 | 36.4 | 14.3 | |
125.00 | 23.7 | 11.3 | 34.9 | 99.0 | 37.1 | 24.9 | 10.9 | |
250.00 | 11.9 | 06.9 | 26.4 | 93.7 | 21.3 | 15.3 | 05.8 | |
500.00 | 05.6 | 03.5 | 13.8 | 81.4 | 09.4 | 06.1 | 03.2 | |
MCF-7 Breast carcinoma |
IC50 (µg/ml) | 29.9 ± 2.3 | 7.6 ± 0.5 | 67.6 ± 4.2 | > 500 | 77.2 ± 5.9 | 30.3 ± 2.6 | 2.9 ± 0.3 |
000.00 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |
001.00 | 100 | 94.1 | 100 | 100 | 100 | 100 | 67.1 | |
002.00 | 100 | 89.2 | 100 | 100 | 100 | 100 | 58.7 | |
003.90 | 99.4 | 78.3 | 100 | 100 | 100 | 99.4 | 52.9 | |
007.80 | 96.2 | 63.1 | 100 | 100 | 100 | 96.2 | 47.2 | |
015.60 | 89.4 | 42.5 | 98.1 | 100 | 98.7 | 89.5 | 40.5 | |
031.25 | 72.3 | 31.7 | 89.7 | 100 | 92.4 | 70.8 | 31.9 | |
062.50 | 40.9 | 23.8 | 74.0 | 100 | 78.1 | 41.7 | 23.8 | |
125.00 | 26.4 | 14.7 | 48.7 | 98.7 | 45.2 | 28.5 | 15.1 | |
250.00 | 13.8 | 07.5 | 32.8 | 91.4 | 30.9 | 18.7 | 07.8 | |
500.00 | 06.7 | 03.8 | 19.4 | 76.8 | 13.7 | 08.9 | 05.4 | |
IC50 (µg/ml) | 53.5 ± 2.3 | 12.8 ± 1.4 | 122 ± 9.3 | >500 | 116 ± 8.2 | 53.6 ± 4.6 | 5.9 ± 0.4 | |
PC-3 Prostate carcinoma |
000.00 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
001.00 | 100 | 100 | 100 | 100 | 100 | 100 | 93.0 | |
002.00 | 100 | 100 | 100 | 100 | 100 | 100 | 88.2 | |
003.90 | 98.0 | 100 | 100 | 100 | 100 | 100 | 74.8 | |
007.80 | 91.7 | 97.8 | 100 | 100 | 98.7 | 100 | 68.9 | |
015.60 | 86.9 | 90.6 | 100 | 100 | 93.8 | 100 | 56.7 | |
031.25 | 71.4 | 79.5 | 97.6 | 100 | 84.1 | 100 | 37.8 | |
062.50 | 43.5 | 64.0 | 93.8 | 99.5 | 67.2 | 99.4 | 24.9 | |
125.00 | 29.4 | 38.1 | 85.1 | 92.4 | 43.9 | 96.2 | 13.7 | |
250.00 | 17.2 | 27.8 | 69.4 | 83.9 | 28.6 | 88.4 | 09.5 | |
500.00 | 08.2 | 15.8 | 46.2 | 70.2 | 15.8 | 74.5 | 05.3 | |
IC50 (µg/ml) | 55.3 ± 5.4 | 96.4 ± 8.3 | 459 ± 24.8 | > 500 | 109 ± 7.8 | > 500 | 21.2 ± 0.9 |
Values are expressed as mean ± SEM of 3 determinants.