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. 2017 Nov 13;26(1):25–32. doi: 10.1016/j.jsps.2017.11.003

Table 6.

The antitumor activity of extracts of Galaxaura rugosa against different cell lines.

Cell line Concentration (µg/ml) Cell viability (%)
Total (Ethanol) Lipoidal matters Chloro-form n-butanol Aqueous Powder Vinblastine sulfate
A-549
Lung carcinoma 		000.00 100 100 100 100 100 100 100
001.00 100 98.1 100 100 100 100 98.2
002.00 98.1 92.3 100 100 100 100 94.7
003.90 94.0 84.9 98.6 100 100 98.4 81.4
007.80 87.3 67.2 93.7 100 98.1 91.7 73.8
015.60 76.9 48.6 85.1 99.2 92.8 85.0 62.5
031.25 63.1 40.9 70.4 95.0 84.0 72.3 40.7
062.50 41.9 32.8 54.8 89.4 69.5 59.1 32.9
125.00 30.6 21.9 38.7 68.1 42.7 38.6 25.2
250.00 22.8 12.8 23.8 40.7 29.4 23.1 15.3
500.00 10.7 06.3 12.9 27.8 14.5 10.9 06.8



CACO-2
Intestinal carcinoma 		IC50 (µg/ml) 50.7 ± 3.5 15 ± 1.7 81.4 ± 4.5 208 ± 17.2 108 ± 9.2 90.4 ± 7.8 24.6 ± 0.7
000.00 100 100 100 100 100 100 100
001.00 100 100 100 100 100 100 99.2
002.00 100 98.7 100 100 100 100 93.8
003.90 100 95.4 100 100 97.8 100 86.2
007.80 99.4 89.2 99.4 97.4 92.4 99.4 79.4
015.60 96.1 72.3 95.2 90.6 85.2 96.2 67.5
031.25 89.2 49.2 84.1 81.4 78.1 89.7 48.9
062.50 72.5 38.4 70.6 68.0 65.7 70.8 31.4
125.00 43.8 27.1 53.4 47.1 42.9 42.9 20.3
250.00 31.7 14.2 34.9 36.2 28.7 28.8 08.9
500.00 16.4 06.4 23.6 21.4 12.5 15.2 04.0
IC50 (µg/ml) 112 ± 10.4 30.7 ± 4.1 149 ± 12.2 117 ± 9.1 106 ± 8.4 109 ± 11.4 30.3 ± 1.4



HCT-116
Colon carcinoma 		000.00 100 100 100 100 100 100 100
001.00 100 79.4 100 100 100 100 66.4
002.00 100 72.9 100 100 100 100 58.1
003.90 98.7 60.7 100 100 100 98.7 47.3
007.80 93.2 45.9 99.1 98.1 100 95.1 39.8
015.60 86.9 38.2 93.7 91.8 99.7 89.5 28.7
031.25 69.1 30.6 86.0 85.2 92.4 73.1 18.9
062.50 43.5 22.8 68.1 68.0 69.5 49.5 15.5
125.00 30.7 16.4 45.2 49.8 42.8 36.9 12.1
250.00 18.6 08.7 31.7 35.4 24.9 23.8 06.7
500.00 06. 03.9 18.6 23.8 08.7 09.2 04.0
IC50 (µg/ml) 54.7 ± 1.2 6.7 ± 0.2 112 ± 7.2 125 ± 5.3 108 ± 3.9 61.9 ± 3.1 3.5 ± 0.2



HeLa
Cervical carcinoma 		000.00 100 100 100 100 100 100 100
001.00 100 92.5 100 100 100 100 100
002.00 99.5 81.4 100 100 100 100 98.1
003.90 94.6 69.0 99.4 100 100 98.4 95.4
007.80 89.7 52.7 96.0 100 97.8 92.3 90.6
015.60 80.9 43.9 88.9 100 91.3 81.4 82.7
031.25 65.2 35.1 80.7 100 80.6 69.8 71.9
062.50 48.1 26.7 68.9 100 62.9 45.1 47.8
125.00 31.4 18.4 47.5 100 43.0 30.6 34.5
250.00 14.7 09.6 31.7 97.1 29.4 21.8 22.8
500.00 08.9 05.7 17.2 89.2 15.8 09.2 09.1
IC50 (µg/ml) 59.1 ± 3.2 10.2 ± 0.6 118 ± 5.1 > 500 103 ± 4.8 56.3 ± 3.4 59.7 ± 2.1



HepG-2
Hepatocellular carcinoma 		000.00 100 100 100 100 100 100 100
001.00 100 90.6 100 100 100 100 60.9
002.00 98.2 83.1 100 100 100 98.7 54.2
003.90 91.7 70.4 99.3 100 98.6 94.0 45.0
007.80 80.1 49.2 94.1 100 91.7 88.7 34.1
015.60 69.4 37.0 86.2 100 82.0 72.1 26.8
031.25 48.1 28.5 72.6 100 67.4 48.5 19.2
062.50 34.5 20.6 51.3 100 53.9 36.4 14.3
125.00 23.7 11.3 34.9 99.0 37.1 24.9 10.9
250.00 11.9 06.9 26.4 93.7 21.3 15.3 05.8
500.00 05.6 03.5 13.8 81.4 09.4 06.1 03.2



MCF-7
Breast carcinoma 		IC50 (µg/ml) 29.9 ± 2.3 7.6 ± 0.5 67.6 ± 4.2 > 500 77.2 ± 5.9 30.3 ± 2.6 2.9 ± 0.3
000.00 100 100 100 100 100 100 100
001.00 100 94.1 100 100 100 100 67.1
002.00 100 89.2 100 100 100 100 58.7
003.90 99.4 78.3 100 100 100 99.4 52.9
007.80 96.2 63.1 100 100 100 96.2 47.2
015.60 89.4 42.5 98.1 100 98.7 89.5 40.5
031.25 72.3 31.7 89.7 100 92.4 70.8 31.9
062.50 40.9 23.8 74.0 100 78.1 41.7 23.8
125.00 26.4 14.7 48.7 98.7 45.2 28.5 15.1
250.00 13.8 07.5 32.8 91.4 30.9 18.7 07.8
500.00 06.7 03.8 19.4 76.8 13.7 08.9 05.4
IC50 (µg/ml) 53.5 ± 2.3 12.8 ± 1.4 122 ± 9.3 >500 116 ± 8.2 53.6 ± 4.6 5.9 ± 0.4



PC-3
Prostate carcinoma 		000.00 100 100 100 100 100 100 100
001.00 100 100 100 100 100 100 93.0
002.00 100 100 100 100 100 100 88.2
003.90 98.0 100 100 100 100 100 74.8
007.80 91.7 97.8 100 100 98.7 100 68.9
015.60 86.9 90.6 100 100 93.8 100 56.7
031.25 71.4 79.5 97.6 100 84.1 100 37.8
062.50 43.5 64.0 93.8 99.5 67.2 99.4 24.9
125.00 29.4 38.1 85.1 92.4 43.9 96.2 13.7
250.00 17.2 27.8 69.4 83.9 28.6 88.4 09.5
500.00 08.2 15.8 46.2 70.2 15.8 74.5 05.3
IC50 (µg/ml) 55.3 ± 5.4 96.4 ± 8.3 459 ± 24.8 > 500 109 ± 7.8 > 500 21.2 ± 0.9

Values are expressed as mean ± SEM of 3 determinants.