Figure 7.

TAT‐MTScs‐FXN treatment FXN‐KO mice. (A) Study design: FA mice model 25 was treated with TAT‐MTScs‐FXN for 4 weeks followed by 2‐week washout. Mice were killed, muscles were harvested at the indicated time‐points (n = 4 per time‐point), and frataxin amounts were evaluated in mitochondrial fractions as described in Materials and methods. (B) Frataxin amounts (expressed in pg/mg of total protein) present in muscle mitochondria of mice treated with 10 mg/kg with TAT‐MTScs‐FXN compared to untreated control (as indicated in the first column). Error bars represent mean ± S.E.M., n = 4 per time‐point.