Figure 3.

CML serum induces M‐MDSC with T cell suppressive ability. (A) Monocytes displayed phenotypic conversion into CD14⁺ HLA‐DR ⁻ after incubation with CML serum for 3 days. Results represent the means of four independent experiment; error bars denote S.D. (B) Suppressive activity of CML serum‐educated M‐MDSC (CML s‐ed M‐MDSC) was evaluated in coculture experiments with CFSE‐labelled autologous T lymphocytes. Mean frequency of CD3⁺ CFSE ^dim cells ± S.D. from four independent experiments in duplicate is shown.