Figure 4.

Effects of CME‐1 on protein phosphatase 2A (PP2A) activation in RAW 264.7 cells. RAW 264.7 cells were treated with CME‐1 (100 μg/ml) for the indicated time. (A) PP2A activity and (B) the dimethyl‐PP2A (deM‐PP2A) protein level were evaluated as described in the Methods. RAW 264.7 cells were pre‐treated with (C) 10 nM OA or (D) 30 μM 3‐OMe‐SM and then treated with CME‐1 (100 μg/ml) for 30 min. Data are presented as the mean ± S.E.M. (n = 3). *P < 0.05, compared with the untreated group; ^# P < 0.05, compared with the CME‐1 group