Table 1.

LEP and LEPR single nucleotide polymorphisms (SNPs) in pathologies associated with pregnancy

Pathologies associated with pregnancy	SNP	Description
Polycystic ovary syndrome	–	No LEP or LEPR SNPs have been described
Recurrent miscarriage	LEP‐2548G/A	GA genotype and G allele are associated with risk of RM
Gestational diabetes mellitus	LEP‐2548G/A	A allele is associated with risk of gestational diabetes mellitus (GDM)
Pre‐eclampsia	LEP‐2548G/A	A allele is associated with PE
	LEPR A223G	G allele is associated with increased risk of severe PE
	LEPRG1019A	GA genotype and G allele are associated with severe PE
	LEPR A668G	A allele is associated with severe PE
Intrauterine growth restriction	–	No LEP or LEPR SNPs have been described