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. 2018 Jan 24;38(4):1015–1029. doi: 10.1523/JNEUROSCI.2010-17.2017

Figure 1.

Figure 1.

IGF-II reverses social interaction deficits and enhances social novelty memory in BTBR mice. Experimental timeline is shown above graphs. In all experiments mice received a subcutaneous injection (↑) of either vehicle (Veh) or IGF-II, 20 min before the first test. All data are expressed as the mean percentage (±SEM). n = 7–9 per group. Two-way ANOVA followed by Tukey or Bonferroni post hoc tests. *p < 0.05, ***p < 0.001. A, Percentage exploration preference for Mouse 1 versus novel object (Test 1), novel Mouse 2 versus Mouse 1 (Test 2), and novel Mouse 3 versus Mouse 1 (Test 3) of B6 and BTBR mice injected with Veh or IGF-II. B, Percentage exploration preference for Mouse 1 versus novel object (Test 1), novel Mouse 2 versus Mouse 1 (Test 2), and novel Mouse 3 versus Mouse 1 (Test 3) of B6 (top) and BTBR (bottom) mice that received a bilateral dorsal hippocampal injections (red ↑) of IGF-IR blocker (JB1), IGF-IIR functionally blocking antibody (Anti), IgG or Veh immediately before a systemic Veh or IGF-II injection. Time spent exploring Mouse 1 versus novel object (Test 1), novel Mouse 2 versus Mouse 1 (Test 2), and novel Mouse 3 versus Mouse 1 (Test 3) of B6 and BTBR mice injected with Veh or IGF-II. Exploration times are reported in the Extended Data (Figs. 1-1 to 1-3. Detailed statistical analyses are reported in the Extended Data tables (Figs. 1-4 to 1-7).