Figure 3.

IGF-II reverses high repetitive behaviors of BTBR mice. Experimental timelines are shown above graphs. In all experiments mice received injections (↑) 20 min before testing. All data are expressed as the mean (±SEM). n = 7–8 per group. Two-way ANOVA followed by Tukey post hoc tests. *p < 0.05, **p < 0.01, ***p < 0.001. A, Time spent burying marbles by B6 and BTBR mice injected with vehicle (Veh) or IGF-II, 20 min before the test. B, Total number of marbles buried by B6 and BTBR mice injected with Veh or IGF-II before test. C, Time spent grooming (Test) 20 min following IGF-II or Veh injections in B6 and BTBR mice. D, Percentage of correct alternations in a Y-maze of B6 and BTBR mice injected with vehicle (Veh) or IGF-II before testing (Test). For detailed statistical analysis see the Extended Data table (Fig. 3-1).