Figure 5.

G9a overexpression during only the acquisition/stabilization phase leads to selective increases in foot-shock stress-induced reinstatement. Shown are paired lever presses over 5 d of extinction (HSV-GFP: n = 5, HSV-G9a: n = 6; a), after noncontingent light and sound cue presentation (HSV-GFP: n = 5, HSV-G9a: n = 5; b), after intraperitoneal injections of saline or cocaine (HSV-GFP: n = 4, HSV-G9a: n = 5; c), or after intermittent foot shocks for 30 min (HSV-GFP: n = 4, HSV-G9a: n = 4; d). Data are expressed as mean ± SEM. *p < 0.05 compared with HSV-GFP.