Figure 11.

Model for inactivation of ARF6 by ELMOD1. A, While ARF6-GTP (and ELMOD1) levels appear to have a broad peak during development; the average response (green dashed line) obscures the sharper peaks of individual cells. ELMOD1 levels peak around the time ARF6-GTP levels do, which produces a transient ARF6-GTP response. B, In the absence of ELMOD1, ARF6-GTP levels are maintained at high levels, increasing the fraction of cells that have elevated ARF6-GTP. C, Biochemical pathways for ARF6 and ELMOD1.