Figure 1.
Depletion of ER Ca2+ stores modulates neuronal excitability of SG neurons in spinal cord slices. A, Representative action potentials generated by increasing series of current injections recorded before (Pre-TG) and 5 min after application of 2 μm TG. B, Summary of changes in the rheobase (df = 6, t = 4.044, p = 0.007), the first-spike latency (df = 15, t = 3.922, p = 0.0014), spike frequency (df = 15, t = 4.935, p = 0.0001) induced by TG in dorsal horn neurons. C, The effect of 3 μm YM 58483 (YM) on TG-induced modulation of the first-spike latency (df = 4, t = 1.195, p = 0.298) and spike frequency (df = 6, t = 0.764, p = 0.474). Values represent mean ± SEM; n = 7–16 neurons; **p < 0.01, ***p < 0.001 compared with pre-TG by the paired Student's t test.