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. 2017 Nov 9;22(2):1056–1069. doi: 10.1111/jcmm.13130

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The role of IL‐10 on myofibroblast activation assessed by immunohistochemical staining and Western blot at day 3 after infarction. Positive staining for α‐SMA (brown color, a hallmark of myofibroblasts) in myocardium is significantly higher in the vehicle, which can be attenuated by administering nicorandil. After adding an IL‐10 receptor antibody (Ab), myofibroblast infiltration was significantly increased compared with nicorandil alone. Vehicle (Veh, n = 7), Nicorandil (Nic, n = 7), Nicorandil/IL‐10 receptor antibody (Nic/Ab, n = 7). *P < 0.05 compared with vehicle and Nic/Ab. ANOVA with Bonferroni's correction.