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. 2018 Jan 24;8:1474. doi: 10.1038/s41598-018-19874-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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None of the tested vectors mediate full maturation of dendritic cells. MoDCs from 3 different HCMV seronegative donors were infected at various MOIs with IE-1 or pp65-expressing vectors. 48 hpi, samples were stained for HLA-DR, CD80, CD83 or CD86 and analyzed via flow cytometry. Panel A shows representative histograms for one donor after transduction with the indicated vectors at MOI 100. The values from all donors and MOIs are summarized in a heatmap (B). Obtained median fluorescence intensity (MFI) values were normalized to those of uninfected cells. Log₂ values which represent the mean (±standard deviation) from all experiments are displayed in a heatmap indicating up-regulation (red) or down-regulation (blue) of a given marker.