Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 24;8:1484. doi: 10.1038/s41598-018-20085-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Longitudinal changes in salivary oral microbiome by caries status. (A and B) Bar graphs indicate the average proportion of each bacterial genus at >1% at baseline (t1) and at the follow-up examination (t2), according to health status: N-N indicates children who remained caries free through the study (n = 14); Y-Y indicates children with caries at both time points (n = 14); N-Y indicates children who were caries-free at baseline and developed caries during the study (n = 5). (A) Total bacterial composition. (B) Detail of non-Streptococcus genera composition. (C) Bacterial composition for individual samples. The heatmap shows colour-coded frequencies for all genera found at >1%. Samples are clustered by their genus-level microbial profile. (D) Richness, number of OTUs in each group (E) Shannon Index of bacterial diversity in each group. (F) Line graphs depicting the change in the mean of each genera of >1% abundance at t1 and t2. The panel label N-N, N-Y, Y-Y indicates group. (G) Samples occupy a position in this Principal Coordinates Analysis (PCoA) according to their bacterial composition as estimated by 16S rRNA gene pyrosequencing. Unweighted Bray-Curtis distances were used (a weighted analysis provided very similar results). Samples are colour-coded according to the health status of children. Circles indicate t1, baseline; triangles indicated t2, follow-up.