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. 2018 Jan 15;373(1741):20160444. doi: 10.1098/rstb.2016.0444

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© 2018 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 2. — Schematic of the impact of short telomeres on murine embryonic stem cell differentiation. As described in Pucci et al. [99], telomere erosion resulted in downregulation of the de novo DNA methyl transferases (Dnmts), and subsequent destabilization of cell differentiation through an inability to suppress the pluripotency factors Nanog, Sox2 and Oct4/Pou5F1. Consequently, stem cells were unable to completely and stably respond to differentiation-inducing cues, and could re-acquire pluripotency gene expression and resume cell proliferation after re-addition of the growth factor LIF (leukaemia inhibitory factor).