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. 2018 Jan 24;8:1491. doi: 10.1038/s41598-018-19473-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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VWF multimer analysis before and after intravitreal injection of aflibercept. We performed VWF multimer analysis in 22 patients with exudative AMD received an intravitreal injection of aflibercept before and at 1 day, 1 week, and 1 month after injection. Of these, VWF multimer analysis of 8 patients (patient Nos. 53–60) were shown in this figure. Each patient number enclosed by a square indicates a patient with polypoidal choroidal vasculopathy (PCV). Patient Nos. 53 and 55 had subretinal hemorrhage and UL-VWFMs before treatment. Patient Nos. 54 and 56 also showed UL-VWFMs before treatment. Patient Nos. 55 and 56 had UL-VWFMs even at 1 month after injection. Asterisks indicate UL-VWFM positivity. NP: normal pool plasma.