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. 2018 Jan 24;8:1491. doi: 10.1038/s41598-018-19473-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma levels of VWF antigen, ADAMTS13 activity, and VEGF-A before and after intravitreal injection of aflibercept in patients with exudative AMD. (A) Plasma levels of VEGF-A were significantly decreased at 1 day after injection (***p < 0.001), and this reduction continued until 1 month after injection (*p < 0.05). (B) Plasma VWF:Ag levels gradually decreased after injection, with a significant reduction starting at 1 week (**p < 0.01). (C) No significant change was observed in ADAMTS13:AC after injection.