Table 1.
Baseline demographics and disease characteristics
| Characteristic | Non-responder (N = 52) | Responder (N = 272) | Robust responder (N = 213) |
|---|---|---|---|
| Age, years, mean (SD) | 65.0 (9.1) | 64.1 (9.0) | 64.0 (0.7) |
| <50 years, n (%) | 4 (7.7%) | 21 (7.7%) | 16 (7.5%) |
| 50–64 years, n (%) | 19 (36.5%) | 112 (41.2%) | 89 (41.8%) |
| 65–74 years, n (%) | 22 (42.3%) | 110 (40.4%) | 87 (40.9%) |
| ≥75 years, n (%) | 7 (13.5%) | 29 (10.7%) | 21 (9.9%) |
| Gender | |||
| Female, n (%) | 24 (46.2) | 115 (42.3%) | 87 (40.9%) |
| Male, n (%) | 28 (53.8) | 157 (57.7%) | 126 (59.1%) |
| BMI, mean (SD) | 23.6 (4.3) | 25.0 (4.6) | 25.1 (4.6) |
| <25, n (%) | 37 (71.2%) | 146 (53.7%) | 114 (53.5%) |
| ≥25, n (%) | 15 (28.8) | 126 (46.3%) | 99 (46.5%) |
| PD duration, years, mean (SD) | 13.2 (5.2) | 12.3 (5.6) | 11.9 (5.6) |
| <4 years, n (%) | 1 (1.9%) | 8 (2.9%) | 8 (3.8%) |
| ≥4 –<7 years, n (%) | 5 (9.6%) | 32 (11.8%) | 27 (12.7%) |
| ≥7 –<10 years, n (%) | 9 (17.3%) | 69 (25.4%) | 57 (26.8%) |
| ≥10–<15 years, n (%) | 22 (42.3%) | 90 (33.1%) | 68 (31.9%) |
| ≥15 –<20 years, n (%) | 10 (19.2%) | 44 (16.2%) | 32 (15.0%) |
| ≥20 years, n (%) | 5 (9.6%) | 29 (10.7%) | 21 (9.9%) |
| Modified Hoehn and Yahr Staging, mean (SD) | 3.1 (0.8) | 3.0 (0.7) | 3.1 (0.7) |
| 2.0, n (%) | 11 (21.2%) | 43 (15.8%) | 30 (14.1%) |
| 2.5, n (%) | 4 (7.7%) | 40 (14.7%) | 30 (14.1%) |
| 3.0, n (%) | 14 (26.9%) | 118 (43.4%) | 96 (45.1%) |
| 4.0, n (%) | 18 (34.6%) | 62 (22.8%) | 52 (24.4%) |
| 5.0, n (%) | 1 (1.9%) | 5 (1.8%) | 2 (0.9%) |
| Missing, n (%) | 4 (7.7%) | 4 (1.5%) | 3 (1.4%) |
| “Off” time, daily hours, mean (SD) | 5.1 (1.7) | 7.0 (2.3) | 7.5 (2.2) |
| ≤3 h, n (%) | 3 (5.8%) | 5 (1.8%) | 0 (0%) |
| >3–4 h, n (%) | 9 (17.3%) | 14 (5.1%) | 4 (1.9%) |
| >4–5 h, n (%) | 11 (21.2%) | 35 (12.9%) | 22 (10.3%) |
| >5–6 h, n (%) | 10 (19.2%) | 49 (18.0%) | 35 (16.4%) |
| >6–7 h, n (%) | 5 (9.6%) | 39 (14.3%) | 32 (15.0%) |
| >7–8 h, n (%) | 5 (9.6%) | 43 (15.8%) | 36 (16.9%) |
| >8 h, n (%) | 3 (5.8%) | 87 (32.0%) | 84 (39.4%) |
| Missing | 6 (11.5%) | 0 | 0 |
| “On” time with TSD, daily hours, mean (SD) | 2.4 (2.2) | 1.5 (2.0) | 1.2 (1.8) |
| “On” time without TSD, daily hours, mean (SD) | 8.5 (2.1) | 8.6 (2.1) | 7.2 (2.4) |
| UPDRS total score, mean (SD) | 45.1 (21.0) | 48.9 (18.6) | 50.0 (18.7) |
| UPDRS Part II score, mean (SD) | 17.6 (7.5) | 17.4 (6.5) | 17.5 (6.3) |
| UPDRS Part III score, mean (SD) | 25.5 (14.0) | 29.3 (13.6) | 30.1 (13.5) |
| PDQ-39 Summary Index, mean (SD) | 45.0 (16.8) | 42.5 (14.7) | 42.0 (14.8) |
| MMSE score, mean (SD) | 28.4 (1.9) | 28.5 (1.6) | 28.5 (1.6) |
BMI body mass index, MMSE mini-mental state examination, PD Parkinson’s disease, PDQ-39 Parkinson’s disease Questionnaire- 39 item, TSD troublesome dyskinesia, UPDRS Unified Parkinson’s Disease Rating Scale