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. 2018 Jan 24;8:1508. doi: 10.1038/s41598-018-19590-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Paclitaxel GWAS. Manhattan plots of paclitaxel disposition GWAS (a) unadjusted and (b) adjusted for paclitaxel dose, glomerular filtration rate (GFR) and aspartate amino transaminase (AST); (c) LocusZoom plot for rs17130142 from the adjusted paclitaxel GWAS. The color shading indicates the strength of LD (r²) from the reference of 1000 Genome Project (CEU samples) between the corresponding SNP and the top SNP, rs17130142. The red horizontal line indicates the genome-wide significance threshold of P = 5 × 10⁻⁸; the blue line is the threshold for putative association (P = 10⁻⁵).