Table 4.
Genetic polymorphisms in ABCC2 associated with carboplatin clearance in the adjusted carboplatin GWAS.
| dbSNP ID | Location | Transcript position | Coding position | Allele | Codons | Amino acid position | Amino acid |
|---|---|---|---|---|---|---|---|
| rs17222723 | exon 25 | 3702 | 3563 | T → A | GTG → GAG | 1188 | Val → Glu |
| rs8187707 | exon 31 | 4627 | 4488 | C → T | CAC → CAT | 1496 | His = His |
| rs8187710 | exon 32 | 4683 | 4544 | G → A | TGC → TAC | 1515 | Cys → Tyr |
| rs11816708 | intergenic | N/A | N/A | T → C | N/A | N/A | N/A |
Abbreviations: Val, valine; Glu, glutamate; His, histidine; Cys, cysteine; Tyr, tyrosine