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. 2018 Jan 24;8:1533. doi: 10.1038/s41598-018-20010-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the RNA constructs consisting of various 5′-terminus of p53 mRNA and the Renilla luciferase coding region. P0 and P1 stand for transcription promoter regions while AUG1 and AUG2 indicate translation start codons. The codon AUG2 was mutated to GUG codon for valine in the P1-Δ40p53(gUG2) and P0-Δ40p53(gUG2) constructs. Nucleotide substitutions in the P1-Δ40p53(L) and P0-Δ40p53(S) constructs are marked on the scheme. In the P1-Δ40p53(Δ57) and P1-Δ40p53(ΔHMD2) constructs two hairpin motifs were mutated (see Fig. 5).