Table 2.
Association of HBGA phenotypes with pre- and post-vaccination IgA titers in RV1 or RV5 vaccinated Nicaraguan children.
| HBGAs phenotype | RV1 (n = 168) | RV5 (n = 68) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | Pre Vaccination IgA GMT (Q1 - Q3) a | Post Vaccination IgA GMT (Q1 - Q3) | Fold-rise in GMT | p value b | n (%) | Pre Vaccination IgA GMT (Q1 - Q3) | Post Vaccination IgA GMT (Q1 - Q3) | Fold-rise in GMT | p value b | |
| Lewis | ||||||||||
| LeB | 119 (71) | 90 (20–320) | 130 (40–640) | 1.4 | 0.001 | 56 (82) | 70 (25–175) | 156 (50–400) | 2.2 | <0.001 |
| LeA-B- | 39 (23) | 85 (20–320) | 119 (40–320) | 1.4 | 0.182 | 8 (12) | 42 (25–50) | 154 (31–1300) | 3.7 | 0.041 |
| LeA | 10 (6) | 90 (20–460) | 96 (35–400) | 1.1 | 0.892 | 4 (6) | 84 (44–175) | 100 (50–400) | 1.2 | 0.593 |
| Secretor | ||||||||||
| Secretor | 156 (93) | 90 (20–320) | 128 (40–400) | 1.4 | <0.001 | 62 (91) | 66 (25–100) | 148 (50–400) | 2.2 | <0.001 |
| Non-secretor | 12 (7) | 75 (20–350) | 95 (40–380) | 1.3 | 0.611 | 6 (9) | 71 (44–125) | 200 (50–700) | 2.8 | 0.138 |
| Blood | ||||||||||
| O | 103 (61) | 100 (20–320) | 149 (40–640) | 1.5 | <0.001 | 49 (72) | 70 (50–100) | 157 (50–400) | 2.2 | <0.001 |
| A | 42 (25) | 74 (20–200) | 101 (20–320) | 1.4 | 0.411 | 10 (15) | 62 (25–125) | 162 (50–800) | 2.6 | 0.116 |
| B | 22 (13) | 74 (18–460) | 87 (20–400) | 1.2 | 0.866 | 9 (13) | 54 (25–150) | 117 (38–400) | 2.1 | 0.027 |
| AB | 1 (0.6) | 80 (80–80) | 80 (80–80) | 1 | N/A | 0 | N/A | N/A | N/A | N/A |
| Overall | 168 | 89 (20–320) | 125 (40–400) | 1.4 | <0.001 | 68 | 67 (25–100) | 152 (50–400) | 2.3 | <0.001 |
aQ1 and Q3 stand for Interquartile 25th and 75th, respectively.
bWilcoxon Signed Ranks Test was used to compare change in rotavirus specific IgA following vaccination. Abbreviations: RV1 = monovalent rotavirus vaccine; RV5 = pentavalent rotavirus vaccine; GMT = geometric mean titer.