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. 2018 Jan 24;8:1541. doi: 10.1038/s41598-018-19387-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypoperfusion-Atrophy hypothesis in AD. The diagram shown our hypothesis about remote effect of medial temporal cortex atrophy on watershed perfusion and watershed hypoperfusion resulted in neuronal dysfunction and finally lead to clinical symptoms. Macro-circulation referred to global or territory blood flow. Microvasculature integrality included neuron, small vessels and autoregulation.