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. 2018 Jan 24;8:1549. doi: 10.1038/s41598-018-19696-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Local Manhattan plot surrounding the peak on chromosome 11. The plot spans a 2 Mb region on chromosome 11. At the top, the SNP indicated in red is the SNP with the highest −log₁₀(P-value) = 9.38 on that chromosome for CBSD symptom severity at 3 MAP. Colours indicate the Pearson’s correlation coefficient (r²) between the top significant GWAS SNP hit on this chromosome and neighboring markers in the given window. Markers with r² > 0.2 in annotated genes are indicated in the panel below.