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. 2018 Jan 24;8:1490. doi: 10.1038/s41598-018-19969-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cellular labelling in flat-mount retinas with the two AAV2 vectors. Panels (a,c and e) are micrographs from an animal that received an injection of the AAV2-CAG-GFP vector while panels (b,d and f) are from an animal that received an injection of the AAV2-DCX-GFP vector. (a,b) Show GFP labelling via intravitreal injection of AAV2-GFP vector (green); (c,d) immunohistochemical labelling of RGCs with RNA binding protein with multiple splicing (RBPMS, red) and (e,f) respective merged images with choline acetyltranferase (ChAT, blue). Scale bars = 50 μm. (g) Density of GFP positive cells from an AAV intravitreal injection and RBPMS positive cells from immunohistochemical labelling. (h) RBPMS+ cells that are GFP+ indicates the proportion of RGCs labelled by GFP and GFP+ cells that are RBPMS+ indicates the specificity of the AAV vector to RGCs. Histograms show means and error bars show 95% confidence intervals; *p < 0.05; n = 6.