FIG 3 .

Relatedness between relapsing parasites and those present in the initial infection. The figure shows the distribution, throughout the genome, of the new alleles (corresponding to patients BL010 [A], BL012 [B], BL002 [C], BL018 [D], and BL011 [E]) that were detected in the relapse infection but not observed in the initial infection. Each cross represents a 10-kb window containing more than five new alleles and is displayed according to its genomic position (x axis, nucleotide position in kilobases; y axis, chromosome). For patient BL10, the new alleles are distributed throughout the genome, suggesting that the initial and relapsing parasites are unrelated (A), while for the other patients, some large chromosomic regions (e.g., most of chromosome 12 in BL12 [B]) are free of new alleles, indicating identical genetic makeup characteristics and close relatedness among the initial and relapsing clones.