Structure and enzymatic activities of phage lytic proteins against S. aureus peptidoglycan. (A) The typical modular structure of phage lytic proteins (endolysins and VAPGHs) is represented by the catalytic domains and the cell wall binding domains (CBDs). (B) The structure of S. aureus peptidoglycan is shown, and the enzymatic activities of the proteins are indicated with an arrow and a number. 1, N-Acetylmuramoyl-l-alanine amidase; 2, interpeptide bridge endopeptidase; 3, l-alanoyl-d-glutamate endopeptidase; 4, N-acetyl-β-d-muramidase; 5, transglycosylase; 6, N-acetyl-β-d-glucosaminidase.