FIG 2 .

Degree of conservation of all GPCR-PIPKs included in this study (top) and sequence logo of the newly identified LRxGI motif (bottom). The degree of conservation was determined by the use of a sliding moving average over 50 positions. The approximate positions of three conserved PIPK motifs (DLGKS, MDYSL, and KK) are indicated. Color coding of amino acid residues in the sequence logo is shown according to chemical properties as follows: red, acidic; blue, basic; black, hydrophobic; purple, neutral; green, polar.