FIG 2 .

Pyruvate causes major changes in production of surface and secreted proteins, including known virulence factors. Surface and secreted proteins from USA300 grown to post-exponential phase (5 h), in the absence (YC) or presence (YCP) of 2% pyruvate, were assessed by quantitative mass spectrometry. (A) Volcano plot. The blue points depict proteins that were significantly changed in the presence of pyruvate. (B to D) Relative fold change in the levels of leucocidins (B), exoenzymes (C), and surface and immunomodulatory proteins (D). Values represent average relative fold changes in three independent cultures ± standard deviations.