Figure 3.

Specific introduction of CART expression into CART neurons in the Arc led to significant decline in body weight in homozygous Cart^cre/cre but not heterozygous Cart^cre/+ mice. Absolute body weight and corresponding body weight change as a percentage of initial body weight measured weekly in Cart^cre/+ (A - B) and Cart^cre/cre (C - D) mice targeted with AAV-Cart or AAV-GFP in the Arc (A, C) or the LHA (B, D) (n = 10 - 12 per group). Data are means ± SEM and averaged for all mice from each group examined. *p ≤ 0.05, **p ≤ 0.01 for AAV-Cart versus AAV-GFP treatments, or for comparisons indicated by horizontal bar.