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. 2017 Nov 6;7:1–11. doi: 10.1016/j.molmet.2017.10.012

Figure 4.

Figure 4

NAMPT overexpression in skeletal muscle partially protected against body weight gain but not against insulin resistance, without behavioral changes in mice fed VHFD. (A) body weight over time, (B) fat mass percentage over time, (C) glucose infusion rate (GIR) during the hyperinsulinemic-euglycemic clamp after 16 weeks fed very high fat diet (VHFD) or chow diet (CD), (D) glucose rate of disposal (Rd) during the hyperinsulinemic-euglycemic clamp after 16 weeks fed very high fat diet (VHFD) or chow diet (CD, (E) oxygen consumption (VO2) over 24 h, and (F) respiratory exchange ratio (RER) over 24 h after 16 weeks fed VHFD or CD. WT CD = Wild Type Chow Diet; NamptTg CD = NamptTg Chow Diet; WT VHFD = Wild Type Very High Fat Diet; NamptTg VHFD = NamptTg Very High Fat Diet. Letters indicate significant differences between groups (p < 0.050). γ p < 0.050 WT VHFD versus WT CD and NamptTg CD; $ p < 0.050 all VHFD versus all CD; ε p < 0.050 WT VHFD versus NamptTg VHFD; δ p < 0.050 WT CD versus WT VHFD and NamptTg VHFD; *p < 0.050 basal versus clamp and light versus dark within the same group. Data are mean ± SEM.