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PTP1B deficiency enhanced an inflammatory response during the MCD diet challenge. A. Hepatic mRNA levels of inflammatory markers. B, C. Analysis of immune NPCs populations. Experimental groups: PTP1BWT and PTP1BKO mice fed chow (CHD) or methionine/choline-deficient diet for 4 (4wMCD) or 8 weeks (8wMCD) (n = 8–12 animals/group). *P < 0.05, **P < 0.01 and ***P < 0.001, PTP1BKO vs. PTP1BWT; #P < 0.05, ##P < 0.01 and ###P < 0.005, 4wMCD or 8wMCD vs. CHD.
