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. 2017 Oct 31;7:132–146. doi: 10.1016/j.molmet.2017.10.008

Figure 8.

Figure 8

Characterization and responsiveness to HGF of oval cell isolated from wild-type and PTP1B-deficient mice treated with DDC. A. Representative images of cytokeratin 19 (CK19) immunostaining. B. Hepatic mRNA levels of oval cell markers. Experimental groups: PTP1BWT and PTP1BKO treated with DDC for 14 days. (n = 6–8 animals/group) *P < 0.05, PTP1BKO vs. PTP1BWT; ##P < 0.01 and ###P < 0.005, DDC vs. CHD. C. Representative images of immunofluorescence of oval cells markers. D. Representative blots with the indicated antibodies and quantification of blots corresponding to all experiments performed. E. Crystal violet assay. PTP1BWT and PTP1BKO oval cells were isolated from wild-type and PTP1B-deficient mice treated with DDC (n = 3 independent experiments performed in triplicate). **P < 0.01 and ***P < 0.005, KO vs. WT; ##P < 0.01 and ###P < 0.005, vs. basal condition.