Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 12;23(2):111–121. doi: 10.1177/2472555217729790

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Society for Laboratory Automation and Screening

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 2. — Potency and maximum efficacy improvements during optimization of PTI-CH. (A) Comparison of relative potency and activity of original hit compound PTI-CA with the optimized compound PTI-CH in the original CFBE41-YFP F508del–cystic fibrosis transmembrane conductance regulator (CFTR) functional assay. (B) Comparison of the relative potency and activity of PTI-CA with PTI-CH in the F508del/F508del human bronchial epithelial (HBE) CFTR functional assay. YFP, yellow fluorescent protein.