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. 2017 Sep 12;23(2):111–121. doi: 10.1177/2472555217729790

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© 2017 Society for Laboratory Automation and Screening

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Figure 5. — The increase in F508del–cystic fibrosis transmembrane conductance regulator (CFTR) does not result in the induction of cytosolic stress or endoplasmic reticulum (ER)–associated unfolded protein response pathways. (A) Quantitative PCR (qPCR) results showing the effect of incubation with PTI-CH for 24 h at the indicated concentrations on the indicated HSF1-regulated messenger RNAs (mRNAs) in F508del/F508del human bronchial epithelial (HBE) cells. (B) qPCR results showing the effect of incubation with PTI-CH for 24 h at the indicated concentrations on the indicated UPR-regulated mRNAs in F508del/F508del HBE cells. Bars represent means, and error bars represent the standard error of the mean (SEM) of three biological replicates.