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. 2018 Jan 23;14:1744806917751322. doi: 10.1177/1744806917751322

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Effect of CCR2 antagonist (INCB3344) on diabetes-induced gastric hyperalgesia. Gastric sensitivity was measured in the control (CT) and diabetic (DM) rats at two weeks after STZ administration. The CCR2 antagonist INCB3344 (CCR2-A) or vehicle (veh) was injected intrathecally. Data are shown as mean ± SEM, ^#p < 0.01, ^†p < 0.05 veh versus CCR2-A, n = 5–7 rats per group. INCB3344 (1 mM and 0.1 mM) significantly suppressed distension-induced gastric hyperalgesia in DM rats at 1 and 2 h after administration as compared with vehicle-treated rats.