Table 1.
Patients demographic, clinical and laboratory data.
| Study population (n = 100) |
IHD (n = 50) |
No IHD (n = 50) |
p-value | |
|---|---|---|---|---|
| Age (years), median (IQR) | 62.0 (54.0–68.0) | 62.5 (58.0–68.3) | 61.0 (49.0–67.3) | 0.123 |
| Male, n (%) | 67 (67.0%) | 37 (68.5) | 30 (65.2) | 0.726 |
| Smoking, n (%) | 31 (31.0%) | 16 (29.6) | 15 (32.6) | 0.748 |
| BMI (kg/m2), median (IQR) | 27.0 (24.0–29.8) | 26.0 (23.0–29.3) | 28.0 (24.0–31.3) | 0.164 |
| Renal failure, n (%) | 20 (20.0) | 13 (24.1) | 7 (15.2) | 0.270 |
| Hypertension, n (%) | 40 (40.0) | 24 (44.4) | 16 (34.8) | 0.326 |
| Diabetes mellitus, n (%) | 32 (32.0) | 19 (35.2) | 13 (28.3) | 0.459 |
| LVEF, median (IQR) | 59.0 (55.0–60.0) | 55.0 (47.3–60.0) | 60.0 (55.0–60.0) | 0.007 |
| Cholic acid, median (IQR) | 14.0 (5.0–40.5) | 9.0 (5.0–32.3) | 19.4 (4.9–46.5) | 0.428 |
| Cholic acid >14 mg/24 h, n (%) | 48 (48.0) | 24 (44.4) | 24 (52.2) | 0.441 |
| Chenodeoxycholic acid, median (IQR) | 8.0 (0.0–21.0) | 8.0 (0.0–22.0) | 6.0 (0.0–20.3) | 0.921 |
| Chenodeoxycholic >8 mg/24 h, n (%) | 44 (44.0) | 25 (46.3) | 19 (41.3) | 0.616 |
| Deoxycholic acid, median (IQR) | 214 (148–374) | 170.5 (116.8–259.0) | 290.5 (188.5–444.0) | <0.001 |
| Deoxycholic acid >214 mg/24 h, n (%) | 49 (49) | 18 (33.3) | 31 (67.4) | 0.001 |
| Lithocholic, median (IQR) | 141.5 (82.3–209.5) | 94.5 (78.8–180.0) | 157.0 (131.3–234.3) | 0.004 |
| Lithocholic >141 mg/24 h, n (%) | 50 (50) | 19 (35.2) | 31 (67.4) | 0.001 |
| Total bile acid, median (IQR) | 416.0 (271.0–628.5) | 344.9 (225.3–523.3) | 597.5 (401.3–725.5) | <0.001 |
| Total bile acids >415 mg/24 h, n (%) | 50 (50) | 18 (33.3) | 32 (69.6) | <0.001 |
| Triglycerides, median (IQR) | 212.5 (167.0–263.5) | 210.5 (142.3–263.8) | 214.5 (183.0–264.4) | 0.516 |
| Triglycerides > mg/dL h, n (%) | 29 (29.0) | 15 (27.8) | 14 (30.4) | 0.770 |
| LDL, median (IQR) | 141.0 (118.3–179.8) | 162.5 (129.5–204.5) | 132.0 (113.5–145.0) | 0.001 |
| LDL >130 mg/dL h, n (%) | 65 (65.0) | 41 (75.9) | 24 (52.2) | 0.013 |
| HDL, median (IQR) | 47.5 (38.0–55.0) | 44.0 (36.0–54.3) | 49.0 (38.0–59.5) | 0.167 |
| HDL <45 mg/dL, n (%) | 47 (47.0) | 29 (61.7) | 18 (39.1) | 0.146 |
| Total cholesterol, median (IQR) | 238.0 (215.3–281.5) | 254.5 (216.0–298.0) | 232.0 (209.0–245.3) | 0.024 |
| Total cholesterol >200 mg/dL h, n (%) | 84 (84.0) | 47 (87.0) | 37 (80.4) | 0.369 |
HDL, high-density lipoprotein; IHD, ischemic heart disease; IQR, interquartile range; LDL, low-density lipoprotein; LVEF, left ventricular ejection fraction.